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pentobarbital will decrease the extent or influence of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with strong CYP3A4 inducers; these drugs minim